Obesity is a major public-health problem worldwide. It has been associated with the development of metabolic syndrome (MS) which is an interrelated cluster of risk factors for cardiovascular disease (CVD) and type 2 diabetes such as hyperglycemia, raised blood pressure, elevated triglyceride levels, low high-density lipoprotein
cholesterol levels, and central obesity. The growing rates of this obesity-related syndrome have spurred the search for greater insight about mechanisms contributing to the development of MS, especially those reflecting a dysfunction of adipose tissue, which probably plays a major role in its development.
Adiponectin, a hormone expressed in adipose tissue and encoded by the ADIPOQ gene (chromosome 3q27), plays an important role in regulating insulin sensitivity, glucose and lipid metabolism besides anti-inflammatory and anti atherogenic properties. Its high molecular weight (HMW) isoform is the major responsible for these
functions. In the presence of obesity, adiponectin release is down regulated resulting in reduced circulating levels.
Key words: Metabolic syndrome, Obesity, Adiponectin.
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