Metabolic syndrome is a combination of metabolic and anthropometric anomalies that directly increase the risk of cardiovascular disease and type 2 diabetes. Metabolic syndrome has become a worldwide health problem due to the pandemic size it has taken. According to doctors, this syndrome is quite problematic because it causes a risk for cardiovascular disease and for type 2 diabetes.
Leptin is mainly secreted by the adipose tissue, and other tissues such as the placenta, the brain, the ovaries, the liver, and the skeletal muscles. Leptin plays an important role in fetal growth and in metabolism, thermogenesis, regulates the onset of puberty, hematopoiesis, osteogenesis and reproductive function.
High levels of leptin and insulin during critical periods of development that in the fetal period lead to hyperphagia, obesity and hyperinsulinemia.The serum leptin values are usually proportional to the amount of adipose tissue, therefore most obese people are considered to be leptin-resistant rather than having leptin deficiency. Plasma leptin values increase with increasing fat mass and descend rapidly in the urine. Leptin stimulates physical activity, heat and energy production. As a pro-inflammatory cytokine affects the regulation of hematopoiesis and lympopoiesis.
Key words: metabolic syndrome, Leptin, Interleukine, lipid status.
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